4.Methods:Animals are sacrified after 10 days, 1 month, 3 months, 7 months

 

Box Number Number of Rats Product Injected Quantity Where Injected How Injected Days of Sacrifice
1 5 NaCl 0.9% 0.1 ml right pretibial muscle IM 10-30-90-120-205
2 5 Endopeel 0.1 ml right pretibial muscle IM 10-30-90-120-205
3 5 Endopeel 0.1 ml right pretibial muscle IM 10-30-90-120-205
4 5 Endopeel 0.1 ml right pretibial muscle IM 10-30-90-120-205
5 5 Endopeel 0.1 ml right pretibial muscle IM 10-30-90-120-205
6 4 Endopeel 0.5 ml above the right pretibial muscle SC     30-90-120-205