Around the year 2000, Dr. Alain Tenenbaum, facial plastic surgeon and Doctor of Science with expertise in signal processing, together with Mauro Tiziani, molecular biologist, conceptualized the development of products and techniques based on a strict separation between input signals and output effects.

The entry signals were designed to be exclusively chemical and to be completely eliminated from the body, primarily via urinary excretion, within approximately 24 hours.

The exit signals, by contrast, were intended to be purely mechanical and consisted of:
– a tissue plasty, allowing three-dimensional reshaping with vectors and orientations deliberately selected by the physician,
– a tissue pexy, corresponding to a lifting effect,
– a restoration of tissue tension, compensating for the progressive loss of biomechanical tone associated with aging.

All of these effects were conceived to occur without adding or removing volume, following a maximally conservative approach.

The conceptual “black boxes” linking entry signals to exit effects were hypothesized to involve viscoelastic elastomer-like behaviors, and, in the initial phase, these techniques were primarily applied to muscular structures.

From the outset, it was considered essential that the chemical inputs should not induce tissue damage and should be fully eliminated after exerting their transient signaling effect.

From 2000 to the present day, the products, techniques, indications, side-effect profiles, and contraindications have undergone substantial development, driven by clinical studies, many of which were multicentric. This evolution was made possible through the contribution of numerous colleagues who explored and defined new indications within their respective fields, including traumatology, gynecology, general surgery, dermatology, oculoplastic surgery, and plastic surgery.

Thanks to the continuous and close collaboration with Mauro Tiziani—formerly a Red Cross chief surgical nurse and later trained in molecular biology—several mechanistic hypotheses were formulated, which appear to correlate closely with the outcomes observed in clinical practice.